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Upcoming and current research projects

Researchers have requested extracts from EpiHealth's database for the following upcoming and current research projects below.

Upcoming Research Projects

Researchers have requested data extraction for the following projects from EpiHealth's database. If you do not want your information to be included in this project, contact Professor Sölve Elmståhl or Professor Lars Lind lars [dot] lind [at] medsci [dot] uu [dot] se.    

More information will be posted soon.

Current Research Projects 


Metabolic Profiling Of Obesity With And Without The Metabolic Syndrome - A Multi-Sample Evaluation
Responsible researcher. Lind L, Salihovic S, Sundström J, Elmståhl S, Hammar U, Dekkers K, Ärnlöv J, Smith JG, Engström G,
Fall T.
There is a dispute whether obesity without major metabolic derangements may represent a benign condition or not. We aimed to compare the plasma metabolome in obese subjects without the metabolic syndrome (MetS) to normal-weight subjects without MetS, as well as to obese subjects with MetS.

Risk Factors For Coronary Artery Disease
Responsible researcher: Brown JC, Gerhardt TE, Kwon E.
Coronary artery disease (CAD) accounts for approximately 610,000 deaths annually (estimated 1 in 4 deaths) and is the leading cause of mortality in the United States. It is the third leading cause of mortality worldwide and is associated with 17.8 million deaths annually. The study reviews the impact and management of risk factors and provides a concise summary of the most recent systemic reviews and evidence. The cohort studies ULSAM, PIVUS, POEM, EpiHealth and SCAPIS are used.


Changes in leisure-time physical activity during the adult life span and relations to cardiovascular risk factors-Results from multiple Swedish studies
Responsible researcher: Lind L, Zethelius B, Lindberg E, Pedersen NL, Byberg L.
Objective: To evaluate how self-reported leisure-time physical activity (PA) changes during the adult life span, and to study how PA is related to cardiovascular risk factors using longitudinal studies.

Evening chronotype is associated with elevated biomarkers of cardiometabolic risk in the EpiHealth cohort: a cross-sectional study
Responsible researcher: Baldanzi G, Hammar U, Fall T, Lindberg E, Lind L, Elmståhl S, Theorell-Haglöw J.
Individuals with evening chronotype have a higher risk of cardiovascular and metabolic disorders, although the underlying mechanisms are not well understood. In a population-based cohort, we aimed to investigate the association between chronotype and 242 circulating proteins from three panels of established or candidate biomarkers of cardiometabolic processes.

NASCENT dietinterventionsstudie (MTIF3)
Responsible researcher: Paul Frank, paul [dot] frank [at] med [dot] lu [dot] se, Lund University
The purpose of this proposed trial is to determine whether the MTIF3 / rs9512699 genotype affects the short- and long-term response to a weight loss intervention.

Perceived stress is related to lower blood pressure in a Swedish cohort
Miguet M, Olivo G, Ciuculete DM, Elmståhl S, Lind L, Schiöth HB.
General psychosocial stress and job strain have been related to blood pressure (BP) with conflicting results. This study sought to explore the contribution of several lifestyle factors in the relation between general psychosocial stress, job strain and BP.


Analysis of loss of chromosome Y (LOY) in leukocytes in severely ill, or deceased male COVID-19 patients; a study based on the EpiHealth cohort
Responsible researcher: Jan Dumanski, Uppsala University
Loss of chromosome Y (LOY) in normal blood cells is strongly associated with a wide range of different outcomes: mortality, various forms of cancer, Alzheimer's disease, autoimmune conditions, age-related macular degeneration, cardiovascular disease, type 2-diabetes, obesity and schizophrenia. It also turns out that among the individuals who are most seriously ill in Covid-19, 75% are men. Mortality in Covid-19 is also higher in men, compared to women.

Genetic variation, neighborhood environment and comorbidity between depression, thromboembolic and cardiovascular disorders: The Epi-health cohort study
Responsible researcher: Jan Sundqvist, Lund University
Knowledge about comorbidities between depression, thromboembolic diseases, cardiovascular diseases as well as diabetes, obesity, and hyperlipidemia is very limited. We will investigate the links between these diseases, partly epidemiologically and partly through experimental analyzes, which will increase the understanding of how the physical and social structure of residential areas, common genetic variants and biological mechanisms at the protein and miRNA level affect these diseases.

Identification and validation of combination biomarkers for early discovery of cancer
Responsible researcher: Tobias Sjöblom, Uppsala University
The research project aims to develop new tests from blood samples for early detection of cancer, so that the disease can be treated as effectively as possible before the cancer has time to spread in the body. Samples from patients who have just been diagnosed with cancer, from the U-CAN cohort (see, will be compared with samples from people without cancer from the EpiHealth cohort. In this way, we seek to find the biological measures, so-called biomarkers, that are best suited for detecting cancer early with high accuracy.

Metabolically healthy obesity (MHO)
Responsible researcher: Lars Lind, Uppsala University
This study aims to investigate whether MHO has an altered proteomics and metabolomic profile, and whether the risk of cardiovascular disease and death is increased.

Number of teeth and common diseases in the elderly - a Mendelian randomization approach
Responsible researcher: Lars Lind, Uppsala University
This study aims to investigate whether periodontitis and the number of teeth an individual has is associated with an altered proteomics and metabolomic profile, as well as the risk of cardiovascular disease and death.

Prediction of severe or mild COVID-19 infection: a study of the prognostic value of underlying chronic disorders, lifestyle factors and genotypes and their consequences on outcome
Responsible researcher: Toralph Ruge, Lund University
Metabolism and cardiovascular disease appear to play a role in the outcome of a COVID-19 infection. This study aims to study how this comorbidity is linked to the severity and outcome of a COVID-19 infection.

Self-reported physical activity as risk factor for CVD
Responsible researcher: Lars Lind, Uppsala University
This study aims to investigate how physical activity is related to CV risk factors, altered proteomics and metabolomic profile, as well as to the risk of cardiovascular disease and death is increased.

Sleep duration is associated with healthy diet scores and meal patterns: results from the population-based EpiHealth study
Responsible researcher: Theorell-Haglöw J, Lemming EW, Michaëlsson K, Elmståhl S, Lind L, Lindberg E.
Study objectives: To investigate relationships between sleep duration and adherence to healthy diets, but also associations with meal patterns, in a large population-based cohort.

Low Physical Activity is Associated with Higher BMI and Body Composition in a Middle-Aged and Elder Swedish Population, whereas Irregular Meals Show Weak Associations
Responsible researcher: Ohlsson B, Manjer J.
Way of life propensities may influence body weight and body structure. Most examinations to look at impacts of way of life factors are acted in more youthful subjects and with estimations of weight record (BMI). The point of the current cross-sectional populace-based investigation was in this manner to investigate relationships between physical action and anomaly of suppers with BMI, fat rate, midsection/hip proportion, and typical weight corpulence (NWO) in a moderately aged and senior Swedish populace.

Sociodemographic and Lifestyle Factors in relation to Overweight Defined by BMI and "Normal-Weight Obesity"
Responsible researcher: Ohlsson B, Manjer J.
Sociodemographic factors and lifestyle habits affect body weight and body composition. A new syndrome, called normal-weight obesity (NWO), is found in individuals with normal weight and excess body fat in contrast to lean and overweight individuals. 

Trail making test research program
Responsible researcher: Lars Lind, Uppsala University
This study aims to investigate whether people with poor brain function (trailmaking test B) have an altered proteomics and metabolomic profile, and whether the risk of cardiovascular disease and death is increased.

The long-term impact of dietary treatment on liver fat content and cardiometabolic control in individuals with prediabetes and type 2 diabetes
Responsible researcher: Ulf Risérus, Uppsala University
The study examines whether different diets in the long term can affect liver fat content and the risk of cardiovascular disease in individuals with prediabetes or type 2 diabetes.


Association Between Self-Reported Sleep Duration and Body Composition in Middle-Aged and Older Adults
Responsible researcher: Tan X, Titova OE, Lindberg E, Elmståhl S, Lind L, Schiöth HB, Benedict C.
The current study sought to examine whether self-reported sleep duration is linked to an adverse body composition in 19,709 adults aged 45 to 75 years.

Cardiometabolic Proteins Associated with Metabolic Syndrome
Responsible researcher: Lind L, Elmståhl S, Ingelsson E.
Although metabolic syndrome (MetS) was described in the late 80s, the molecular mechanisms underlying clustering of risk factors in certain individuals are not fully understood. The present study used targeted proteomics to establish cardiometabolic proteins related to all MetS components, thereby providing new hypotheses regarding pathways involved in the pathogenesis of MetS.

Dietary Pattern Specific Protein Biomarkers for Cardiovascular Disease: A Cross-Sectional Study in 2 Independent Cohorts
Responsible researcher: Warensjö Lemming E, Byberg L, Stattin K, Ahmad S, Lind L, Elmståhl S, Larsson SC, Wolk A, Michaëlsson K.
Mechanisms related to the influence of diet on the development of cardiovascular disease are not entirely understood, and protein biomarkers may help to understand these pathways. We have discovered and replicated independent associations between dietary patterns and 21 biomarkers linked to cardiovascular disease, which have a role in the pathways related to inflammation, endothelial and immune function, cell adhesion, and metabolism.

In search of causal pathways in diabetes: a study using proteomics and genotyping data from a cross-sectional study
Responsible researcher: Beijer K, Nowak C, Sundström J, Ärnlöv J, Fall T, Lind L.
The pathogenesis of type 2 diabetes is not fully understood. We investigated whether circulating levels of preselected proteins were associated with the outcome 'diabetes' and whether these associations were causal.

Lung function in LifeGene and EpiHealth
Responsible researcher: Andrei Malinovschi, Uppsala University
Impaired lung function is a growing problem in society. In order to be able to determine which people have impaired lung function, we want to study relevant reference values ​​for the population that is being studied. Furthermore, we want to investigate connections between impaired lung function and common risk factors for cardiovascular disease.

Lung function and proteomics and metbolomics in EpiHealth
Responsible researcher: Andrei Malinovschi, Uppsala University
Impaired lung function is a growing problem in society. Studies have shown an association between impaired lung function and cardiovascular death. An underlying mechanism has been suggested to be changes in the body's proteins. The purpose of this study is to investigate whether there is any connection between lung function and what the protein profile looks like in individuals who have risk factors for cardiovascular disease (lipid disorders, obesity and smoking).

Physical activity is associated with a large number of cardiovascular-specific proteins: Cross-sectional analyses in two independent cohorts
Responsible researcher: Stattin K, Lind L, Elmståhl S, Wolk A, Lemming EW, Melhus H, Michaëlsson K, Byberg L.
We aimed to discover and replicate associations between leisure-time physical activity and cardiovascular candidate plasma protein biomarkers and to examine whether the associations were independent of body fat.

Population-based cardiovascular cohort studies in Uppsala
Responsible researcher: Lind L.
Cardiovascular-oriented studies constitute a very rich source for cardiovascular epidemiological research in Uppsala. This review summarizes the design of these studies and highlights some of the important results published based on data from these studies.

Seasonal and regional variations in self-reported sleep duration and sleep complaints: the Epihealth study - Inverkan av livsstil och genetik på mental hälsa
Responsible researcher: Christian Benedict, Uppsala University
Many studies have shown that lack of sleep has a negative effect on human health and cognitive ability. The purpose of this study is to investigate whether there are seasonal variations in self-reported sleep duration and sleep disorders in adults. In addition, we want to investigate whether there are regional differences in sleeping habits between residents in Malmö and Uppsala.